Type XII RTKs: TIE family of angiopoietin receptors C

Formerly known as: TIE family of angiopoietin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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The TIE family were initially associated with formation of blood vessels. Endogenous ligands are angiopoietin-1 (ANGPT1, Q15389), angiopoietin-2 (ANGPT2, O15123), and angiopoietin-4 (ANGPT4, Q9Y264). Angiopoietin-2 (ANGPT2, O15123) appears to act as an endogenous antagonist of angiopoietin-1 function.


Targets of relevance to immunopharmacology are highlighted in blue

TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) C Show summary » More detailed page

TIE2 (TEK receptor tyrosine kinase) C Show summary » More detailed page

How to cite this family page

Database page citation:

Type XII RTKs: TIE family of angiopoietin receptors. Accessed on 22/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=330.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.