Type II receptor serine/threonine kinases C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
The type II protein phosphorylates the kinase domain of the type I partner (sometimes referred to as the signal propagating subunit), causing displacement of the protein partners, such as the FKBP12 FK506-binding protein FKBP1A (P62942) and allowing the binding and phosphorylation of particular members of the Smad family.
Receptors
Targets of relevance to immunopharmacology are highlighted in blue
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ActR2 (activin A receptor type 2A) C
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ActR2B (activin A receptor type 2B) C
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MISR2 (anti-Mullerian hormone receptor type 2) C
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BMPR2 (bone morphogenetic protein receptor type 2) C
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TGFBR2 (transforming growth factor beta receptor 2) C
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Further reading
How to cite this family page
Database page citation:
Type II receptor serine/threonine kinases. Accessed on 23/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=319.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.
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