IL-12 receptor family C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
IL-12 receptors are a subfamily of the IL-6 receptor family. IL12RB1 is shared between receptors for IL-12 and IL-23; the functional agonist at IL-12 receptors is a heterodimer of IL-12A/IL-12B, while that for IL-23 receptors is a heterodimer of IL-12B/IL-23A.
Receptors
Targets of relevance to immunopharmacology are highlighted in blue
Complexes
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Interleukin-12 receptor
C
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Interleukin-23 receptor
C
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Receptors and Subunits
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Interleukin-12 receptor, β1 subunit
C
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Interleukin-12 receptor, β2 subunit
C
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Interleukin 23 receptor
C
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Further reading
How to cite this family page
Database page citation:
IL-12 receptor family. Accessed on 23/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=308.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.
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