IL-3 receptor family | Catalytic receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

IL-3 receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The IL-3 receptor family signal through a receptor complex comprising of a ligand-specific α subunit and a common β chain (CSF2RB, P32927), which is associated with Jak2 and signals primarily through Stat5.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

Complexes

Interleukin-3 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-5 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Granulocyte macrophage colony-stimulating factor receptor C Show summary »« Hide summary More detailed page go icon to follow link

Receptors and Subunits

Interleukin 3 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 5 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

GM-CSF receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Cytokine receptor common β subunit C Show summary »« Hide summary More detailed page go icon to follow link

References

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1. Cohen ES, Minter RR, Harrison PR, Sleeman MA, Nash AD, Fabri LJ. (2012) Antibody molecule for human GM-CSF receptor alpha. Patent number: US8263075. Assignee: Medimmune Limited. Priority date: 27/03/2006. Publication date: 11/09/2012.

2. Koike M, Spitalny GL, Wheeler A, White B. (2013) Methods of reducing eosinophil levels. Patent number: US8501176. Assignee: Medimmune, Llc, Biowa, Inc.. Priority date: 14/05/2007. Publication date: 06/08/2013.

3. Morokata T, Ida K, Yamada T. (2002) Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int Immunopharmacol, 2 (12): 1693-702. [PMID:12469943]

How to cite this family page

Database page citation:

IL-3 receptor family. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=306.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.