Glycoprotein hormone receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Glycoprotein hormone receptors (provisional nomenclature [1]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit (CGA, P01215) CGA, P01215), with a unique β chain that confers the biological specificity to FSH (CGA, FSHB, P01215, P01225), LH (LHB, CGA, P01229, P01215), hCG (CGA, CGB3, P01233, P01215) or TSH (TSHB, CGA, P01222, P01215). There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [4].


Targets of relevance to immunopharmacology are highlighted in blue

FSH receptor C Show summary » More detailed page

LH receptor C Show summary » More detailed page

TSH receptor C Show summary » More detailed page

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Deborah L. Segaloff, Gilbert Vassart, Sabine Costagliola, James A. Dias, Marvin Gershengorn, Axel P.N. Themmen. Glycoprotein hormone receptors. Accessed on 20/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.