Protein kinase A (PKA) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Cyclic AMP-mediated signalling involves regulation of cyclic nucleotide-gated ion channels, members of the Rap guanine nucleotide exchange family (Epac, ENSFM00250000000899) and activation of protein kinase A (PKA, also known as cyclic AMP-dependent protein kinase). PKA is a heterotetrameric enzyme composed of two regulatory and two catalytic subunits, which can be distinguished from Epac (exchange protein directly activated by cyclic AMP, [2]) by differential activation by N⁶ benzyl-cAMP (see Table) and 8-pCPT-2'-O-Me-cAMP, respectively [3].

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

Complexes

protein kinase A Show summary »« Hide summary More detailed page go icon to follow link

Enzymes and Subunits

PKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha subunit) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1472
Nomenclature	protein kinase, cAMP-dependent, regulatory, type I, alpha subunit
Common abbreviation	PKAR1A
Previous and unofficial names	TSE1 \| tissue specific extinguisher 1 \| protein kinase, cAMP dependent regulatory, type I, alpha \| RIIA \| RIalpha \| PRKAR1 \| protein kinase, cAMP-dependent, regulatory subunit type I alpha \| protein kinase \| protein kinase cAMP-dependent type 1 regulatory subunit alpha
Complexes	protein kinase A
Genes	PRKAR1A (Hs), Prkar1a (Mm), Prkar1a (Rn)
Ensembl ID	ENSG00000108946 (Hs), ENSMUSG00000020612 (Mm), ENSRNOG00000049876 (Rn)
UniProtKB AC	P10644 (Hs), Q9DBC7 (Mm), P09456 (Rn)

PRKAR1B (protein kinase, cAMP-dependent, regulatory, type I, beta subunit) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1473
Nomenclature	protein kinase, cAMP-dependent, regulatory, type I, beta subunit
Common abbreviation	PRKAR1B
Previous and unofficial names	Prkar1b \| protein kinase, cAMP dependent regulatory, type 1 beta \| RIbeta \| cAMP-dependent protein kinase type I-beta regulatory subunit \| protein kinase, cAMP-dependent, regulatory subunit type I beta \| protein kinase, cAMP dependent regulatory, type I beta \| protein kinase \| protein kinase cAMP-dependent type 1 regulatory subunit beta
Complexes	protein kinase A
Genes	PRKAR1B (Hs), Prkar1b (Mm), Prkar1b (Rn)
Ensembl ID	ENSG00000188191 (Hs), ENSMUSG00000025855 (Mm), ENSRNOG00000028733 (Rn)
UniProtKB AC	P31321 (Hs), P12849 (Mm), P81377 (Rn)

PRKAR2A (protein kinase, cAMP-dependent, regulatory, type II, alpha subunit) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1474
Nomenclature	protein kinase, cAMP-dependent, regulatory, type II, alpha subunit
Common abbreviation	PRKAR2A
Previous and unofficial names	PRKAR2 \| protein kinase cAMP-dependent regulatory type II alpha \| RII(alpha) \| PKR2 \| protein kinase, cAMP-dependent, regulatory subunit type II alpha \| protein kinase \| protein kinase cAMP-dependent type 2 regulatory subunit alpha
Complexes	protein kinase A
Genes	PRKAR2A (Hs), Prkar2a (Mm), Prkar2a (Rn)
Ensembl ID	ENSG00000114302 (Hs), ENSMUSG00000032601 (Mm), ENSRNOG00000020284 (Rn)
UniProtKB AC	P13861 (Hs), P12367 (Mm), P12368 (Rn)

PKAR2B (protein kinase, cAMP-dependent, regulatory, type II, beta subunit) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1475
Nomenclature	protein kinase, cAMP-dependent, regulatory, type II, beta subunit
Common abbreviation	PKAR2B
Previous and unofficial names	PRKAR2 \| Type II beta regulatory subunit of cAMP-dependent protein kinase \| Pkarb2 \| RII(beta) \| protein kinase, cAMP-dependent, regulatory, type II, beta \| cAMP-dependent protein kinase type II-beta regulatory subunit \| protein kinase, cAMP dependent regulatory, type II beta \| protein kinase, cAMP-dependent, regulatory subunit type II beta \| protein kinase \| protein kinase cAMP-dependent type 2 regulatory subunit beta
Complexes	protein kinase A
Genes	PRKAR2B (Hs), Prkar2b (Mm), Prkar2b (Rn)
Ensembl ID	ENSG00000005249 (Hs), ENSMUSG00000002997 (Mm), ENSRNOG00000009079 (Rn)
UniProtKB AC	P31323 (Hs), P31324 (Mm), P12369 (Rn)

PKACa (protein kinase, cAMP-dependent, catalytic, alpha subunit) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1476

Nomenclature

protein kinase, cAMP-dependent, catalytic, alpha subunit

Common abbreviation

PKACa

Previous and unofficial names

Complexes

protein kinase A

Genes

PRKACA (Hs), Prkaca (Mm), Prkaca (Rn)

Ensembl ID

ENSG00000072062 (Hs), ENSMUSG00000005469 (Mm), ENSRNOG00000005257 (Rn)

UniProtKB AC

P17612 (Hs), P05132 (Mm), P27791 (Rn)

EC number

2.7.11.11

PKACb (protein kinase, cAMP-dependent, catalytic, beta subunit) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1477

Nomenclature

protein kinase, cAMP-dependent, catalytic, beta subunit

Common abbreviation

PKACb

Previous and unofficial names

PKA C-beta | cAMP-dependent protein kinase C beta | protein kinase, cAMP-dependent, catalytic, beta | protein kinase, cAMP-dependent, beta catalytic subunit | protein kinase

Complexes

protein kinase A

Genes

PRKACB (Hs), Prkacb (Mm), Prkacb (Rn)

Ensembl ID

ENSG00000142875 (Hs), ENSMUSG00000005034 (Mm), ENSRNOG00000004978 (Rn)

UniProtKB AC

P22694 (Hs), P68181 (Mm), P68182 (Rn)

EC number

2.7.11.11

PKACg (protein kinase, cAMP-dependent, catalytic, gamma subunit) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1478

Nomenclature

protein kinase, cAMP-dependent, catalytic, gamma subunit

Common abbreviation

PKACg

Previous and unofficial names

protein kinase, cAMP-dependent, gamma catalytic subunit

Complexes

protein kinase A

Genes

PRKACG (Hs)

Ensembl ID

ENSG00000165059 (Hs)

UniProtKB AC

P22612 (Hs)

EC number

2.7.11.11

PRKX (protein kinase X-linked) Show summary »« Hide summary More detailed page go icon to follow link

PRKY (protein kinase Y-linked (pseudogene)) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2176

Nomenclature

protein kinase Y-linked (pseudogene)

Common abbreviation

PRKY

Previous and unofficial names

PRKXP3 | protein kinase, Y-linked, pseudogene

Genes

PRKY (Hs)

Ensembl ID

ENSG00000099725 (Hs)

UniProtKB AC

O43930 (Hs)

EC number

2.7.11.1

Comments

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References

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1. Christensen AE, Selheim F, de Rooij J, Dremier S, Schwede F, Dao KK, Martinez A, Maenhaut C, Bos JL, Genieser HG et al.. (2003) cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. J Biol Chem, 278 (37): 35394-402. [PMID:12819211]

2. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL. (1998) Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature, 396 (6710): 474-7. [PMID:9853756]

3. Kang G, Chepurny OG, Rindler MJ, Collis L, Chepurny Z, Li WH, Harbeck M, Roe MW, Holz GG. (2005) A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells. J Physiol (Lond.), 566 (Pt 1): 173-88. [PMID:15860526]

4. Schiebel K, Winkelmann M, Mertz A, Xu X, Page DC, Weil D, Petit C, Rappold GA. (1997) Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. Hum Mol Genet, 6 (11): 1985-9. [PMID:9302280]

How to cite this family page

Database page citation:

Protein kinase A (PKA) family. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=284.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.