Within the SLC13 family, two groups of transporters may be differentiated on the basis of the substrates transported: NaS1 and NaS2 convey sulphate, while NaC1-3 transport carboxylates. NaS1 and NaS2 transporters are made up of 13 TM domains, with an intracellular N terminus and are electrogenic with physiological roles in the intestine, kidney and placenta. NaC1, NaC2 and NaC3 are made up of 11 TM domains with an intracellular N terminus and are electrogenic, with physiological roles in the kidney and liver.

* Key recommended reading is highlighted with an asterisk

* Bergeron MJ, Clémençon B, Hediger MA, Markovich D. (2013) SLC13 family of Na⁺-coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med, 34 (2-3): 299-312. [PMID:23506872]

Lee A, Dawson PA, Markovich D. (2005) NaSi-1 and Sat-1: structure, function and transcriptional regulation of two genes encoding renal proximal tubular sulfate transporters. Int J Biochem Cell Biol, 37 (7): 1350-6. [PMID:15833267]

Markovich D. (2011) Physiological roles of renal anion transporters NaS1 and Sat1. Am J Physiol Renal Physiol, 300 (6): F1267-70. [PMID:21490138]

* Markovich D. (2014) Na+-sulfate cotransporter SLC13A1. Pflugers Arch, 466 (1): 131-7. [PMID:24193406]

Markovich D, Aronson PS. (2007) Specificity and regulation of renal sulfate transporters. Annu Rev Physiol, 69: 361-75. [PMID:17002596]

Markovich D, Murer H. (2004) The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch, 447 (5): 594-602. [PMID:12915942]

* Pajor AM. (2014) Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family. Pflugers Arch, 466 (1): 119-30. [PMID:24114175]

* Zhang L, Hu W, Qiu Z, Li Z, Bian J. (2023) Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery. J Med Chem, 66 (14): 9229-9250. [PMID:37428122]

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4. Zahn G, Willmes DM, El-Agroudy NN, Yarnold C, Jarjes-Pike R, Schaertl S, Schreiter K, Gehrmann W, Wong AKC, Zordan T et al.. (2022) A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity. Metabolites, 12 (8): 732. [PMID:36005604]

5. Zhang L, Hu W, Qiu Z, Li Z, Bian J. (2023) Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery. J Med Chem, 66 (14): 9229-9250. [PMID:37428122]